Bulk Transport – LDL Receptor-Mediated Endocytosis: Sometimes cell…

Bulk Transport – LDL Receptor-Mediated Endocytosis: Sometimes cell membranes must assist in regulating transport of materials that are too large, or bulky, to move through proteins. In these cases, cell membranes can create small membrane-bound vesicles that can assist with either releasing bulk materials from the cell or bringing bulk material into the cells.
In your last Application assignment, you studied whether cholesterol was a component of food in your diet. You are probably aware that high cholesterol in your diet can accumulate in the blood in bulky lipid-protein particles known as low-density lipoproteins (LDL’s). High levels of LDL (sometimes called bad cholesterol) in the blood can cause them to build up and narrow or block arteries, which leads to higher risk of heart disease.
Interestingly, the cells of your body, most particularly your liver cells, can assist with taking up LDL particles by binding it to receptors on the cell surface and bringing it into the cell via endocytosis for degradation. Review the Chapter 3 material on endocytosis and exocytosis and supplement this information by accessing this Biotech Review video on Receptor Mediated Endocytosis to better visualize this process.
10. How does this process of receptor-mediated endocytosis differ from phagocytosis? How does it differ from pinocytosis?
11. Describe the process of LDL receptor-mediated endocytosis in a step by step fashion.
12. How does the process of endocytosis differ from the process of exocytosis?

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